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One extensively studied polymorphism is rs2234694 (+35A/C), situated at the junction site between the intron and exon 3 (Ben Anes et al., 2019
Dietary phytoestrogens and their role in hormonally dependent disease
Deficiency of selenium in serum or cytoplasm may impair the function of GPX4, eventually leading to the accumulation of lipid peroxides, which in turn leads to ferroptosis (Friedmann Angeli and Conrad, 2018)
This is followed by the activation of the STAT3 pathway and the induction of M2 polarization, accompanied by upregulation of IL-10 (117)
