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In vivo experiments demonstrated that pharmacological inhibition of carnitine transport by meldonium, tetrahydropalmatine or quinidine suppressed tumour growth and sensitised tumours to chemotherapy and immunotherapy

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This systematic review of the 13 controlled trials in 3,629 patients, involving 250 deaths, 220 cases of new heart failure, and 38 recurrent heart attacks, found that L-carnitine was associated with: Advertisement Significant 27% reduction in all-cause mortality (number needed to treat 38) Highly significant 65% reduction in ventricular arrhythmias (number needed to treat 4) Significant 40% reduction in the development of angina (number needed to treat 3) Reduction in infarct size There were numerically fewer myocardial reinfarctions and heart failure cases associated with L-carnitine, but this did not reach statistical significance.First author James J