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Median age was 44 years (range, 2558 years), 11 (69%) were male, and median number of prior biologic exposures was 3 (range, 25)
4.1 Complexity of GB biology Intra-tumoral heterogeneity, which has also been previously described in GB using single-cell RNA-seq profiling ( Redundant signaling pathways in gliomagenesis limit the effectiveness of targeted therapies that focus on a single gene or pathway, even when the tumors complete molecular profile is known
