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Description
The capability of DON to cross the BBB depends on the animal species

In connective tissue, ZIP7 deficiency impairs protein disulfide isomerase function, leading to defective ER-folding capacity and disrupted development of the dermis, bone and teeth, as demonstrated in connective-tissue-specific ZIP7-knockout mice 69

doi: 10.1016/S0005-2736(01)00454-0

Gut Lining and Mucosal Healing Studies Preclinical work shows BPC-157 acting on the gut through several connected mechanisms