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In vivo , IPI549 improved the anti-tumor efficacy of paclitaxel in tumor xenograft model of P-gp-overexpressing SW620/Ad300 colon cancer with a ratio of growth inhibition for tumor volume (IRV) = 74% and for tumor weight (IRW) = 72%, compared to 42% IRV and 37% IRW for the paclitaxel alone treatment (De Vera et al., 2019)

For a complete understanding of paraxanthine's benefits and mechanisms, be sure to read our comprehensive guide, Paraxanthine: Caffeine's Major Metabolite for Laser-Targeted Energy

10.1016/j.freeradbiomed.2021.10.028 281 TsaiM.-S.LiouG.-G.LiaoJ.-W.LaiP.-Y.YangD.-J.WuS.-H.et al (2024)

GPx steps in as the firefighter, using a special tool called glutathione (GSH) to douse these flames before they spread