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To date, these responses appear to involve the ORE, AP-1, NFB, and p53 sites

MT1X is an oncogene and indicates prognosis in ccRCC

Although less evidence comes from selected clinical trials data, which are summarized in Table 2

Indoxyl sulfate, a uremic toxin, stimulates reactive oxygen species production and erythrocyte cell death supposedly by an organic anion transporter 2 (OAT2) and NADPH oxidase activity-dependent pathways
