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Pro-Resolving Lipid Mediators Are Leads for Resolution Physiology
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Although Syn wild-type ( WT ) has a hydrophobic (NAC) core, it is shielded by long-range intramolecular interactions, rendering it inert. In contrast, Parkinsons disease (PD)-specific Syn variantsS129 phosphorylation and C-terminal truncationsaggregate and phase separate more rapidly, suggesting hydrophobic exposure
Additional file 3: Figure 3B), a finding recently associated with the pathophysiology of different neurodegenerative diseases [37,38,39]
