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J Clin Oncol, 2020 Gastrointestinal Cancers Symposium 38(suppl 4), 2020
Genetic and biochemical data have shown that LRRK2 pathogenic variants particularly Gly2019Ser and variants in the GTPase Roc and COR domains of the protein cause a toxic, gain-of-function-mechanism mediated hyperactivity of LRRK2 kinase (Chan et al
Psychiatry 145 , 844848 (1988)
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