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Free radical initiated oxidation is one of these external actions and one of the most important antioxidants [3], used as a defense mechanism, is a small tripeptide, glutathione (-L-glutamyl-L-cysteinyl-glycine, GSH, Figure 1 )

Decreased expression of HNF4 by miR-34a in turn decreases cAMP-responsive element binding protein H (CREBH), which impairs VLDL assembly and secretion, leading to lipid accumulation in hepatocytes and possibly contributing to hepatic steatosis [299]

Nevertheless, an ever-increasing number of studies demonstrate the key involvement of the stress hormone-induced epigenetic alterations in cells constituting the stress system, and its regulatory brain centres may be involved in this process [9496]

The keywords used were: ferroptosis, recurrent miscarriage, recurrent pregnancy loss, decidua, trophoblast, oxidative stress, and iron metabolism. Inclusion criteria: Original research articles and reviews focusing on ferroptosis and recurrent miscarriage