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Furthermore, 2-ME2 disrupts tubulin organization in HASMCs by binding to colchicine sites, thereby impeding mitosis and suppressing HIF-1 activity, which further inhibits cell proliferation [71, 77, 79, 80]

Autophagy impairment induces premature senescence in primary human fibroblasts

Camphene also reduces ROS levels induced by starvation and hydrogen peroxide in both in vitro and in vivo models, improving muscle atrophy induced by starvation in rats
