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41 MacFabeD
doi: 10.1124/jpet.102.047712
Opioids (Tramadol and Oxycodone) considered third-line treatments for DPN, used only when previous therapies are ineffective
Preclinical studies have shown that cysteamine levels and vanin-1 activity can be elevated in certain disease states associated with oxidative stress, which is often increased in diabetes 9,12,13
