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Ungvari Z, Bagi Z, Feher A, Recchia FA, Sonntag WE, Pearson K, et al

and C.J.R

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The H3 receptors are acting as a feedback loop to restrict histamine and other neurotransmitter release in certain brain regions.[ref] The study also linked histaminergic neuron expression and changes in the brain to ADHD and major depressive disorder