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Description
Increases in calcitonin levels have been observed in some patients, though the clinical significance remains uncertain
This proof of concept has been confirmed by a large number of preclinical studies and several early clinical trials, which provide encouraging results in regenerative effect and reducing low back pain, respectively 42
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These values are compatible with the solvation free energy of the proton of -253.4, -253.2 and -261.1 kcal mol-1 in H2O, CH3CN and DMSO solvents, resp
