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It has been reported that the myocardial infarction increases NOX2-derived ROS that activated apoptotic pathways such as Apoptosis signal-regulating kinase 1-p38 pathway ((ASK-1)-p38MAPK) and Ca 2+ /calmodulin-dependent protein kinase II (CAMKII)

[DOI] [PMC free article] [PubMed] [Google Scholar] 48.Tepes M., Krezic I., Vranes H., Smoday I.M., Kalogjera L., Zizek H., Vukovic V., Oroz K., Kovac K.K., Madzar Z., et al

& Elias, E

Those are two completely different contexts, patients, and purposes one has nothing to do with the other, and the chemo dose is not something to replicate for cosmetic reasons