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Description
Hepatology 2008, 48 (5), 14771486
Liao MT, Wu CC, Wu SV, Lee MC, Hu WC, Tsai KW, Yang CH, Lu CL, Chiu SK, Lu KC
By identifying a core set of 62 cross-validated mitochondrial genes and establishing high-confidence metabolite-gene correlations (notably MTHFR-homocysteine and PDHA1-acetyl-CoA), the authors demonstrate significant sex-dimorphic flux alterations within the tricarboxylic acid (TCA) cycle and mitochondrial transport subsystems, particularly pronounced in females
In parallel, microRNAs (miRNAs) have emerged as crucial regulators of inflammatory and metabolic pathways that further modulate these processes
