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The damaging effects of Nrf2 modification in the lung, as an example, may increase the susceptibility of the affected tissues to the oxidative stress of the oxygen environment, as well as compromise the function of epithelial cells and phagocytes, such as granulocytic leukocytes and monocytes/macrophages [49,50]

244 Using large-scale in vivo CRISPR screening technology, researchers have identified the E3 ligase Cop1 within breast cancer cells as an essential regulator of macrophage chemokine secretion
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The Palm Beach Gardens Fire Department was chartered on October 9, 1963, operating from a garage at the present-day location of the fire station at Burns Road and Military Trail, and utilizing an old pickup truck with hose donated by MacArthur