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Currently, there has only been one double-blinded randomized placebo-controlled clinical trial for EGCG on eye disease, and none for the sole green tea extract treatment

Immunofluorescence microscopy

Their hypomethylation, especially in the regions called Long Interspersed Nucleotide Element 1 (LINE-1), has been observed in virtually all human cancers and is frequently associated with a poor prognosis [70]
