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doi: 10.1016/j.cmet.2010.04.016

Sinha K, Das J, Pal PB, Sil PC (2013) Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosis

Melena happens when blood originates from more proximal sections of the GI tract, such as the small intestine, or when bleeding from a lower source happens slowly enough to allow for the enzymatic breakdown of haemoglobin
