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The RAS/RAF/MEK/ERK kinase cascade enhances the translation of HIF-1 by phosphorylating eukaryotic translation initiation factor 4E ( eIF-4E )
As a result, data are heterogenous, with beneficial effects of weight loss on disability and cardiometabolic health, but also important risks that may be forgotten about by clinicians
It has been extensively studied for its role in sleep regulation, neuroendocrine balance, and stress adaptation
