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The pathogenesis is not fully understood yet
Clinical analyses indicate that MAFLD-associated HCC patients typically present with older age at diagnosis, larger tumor dimensions, and more advanced disease stages
however, GPx1 expression regulates the response to kainic acid in an unexpected manner: GPx1 knockout mice are more resistant to kainic acid-induced epileptic seizures than wildtype mice and transgenic GPx1 mice have augmented responses to kainic acid exposure [117, 118]
