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Institutional animal care and use committee statement: Male Albino Wistar, body weight 200 g, 12 weeks old, randomly assigned, used in all of the experiments, 6 rats/group/interval, approved by local Ethic Committee

Farmacocintica No se localiz farmacocintica humana validada (vida media, biodisponibilidad) en fuentes revisadas por pares para ninguno de los tres componentes en esta investigacin

Mechanisms of OR desensitization OR phosphorylation Numerous studies have been carried out to demonstrate the role of OR phosphorylation in desensitization by using chemical inhibitors of kinases, in vitro or in vivo knock-out (KO) of kinases using siRNA or transgenic mice, over-expression of dominant negative mutants of kinases, amino acid substitution or truncation on OR

Yet, aneuploidy comes at a cost