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Also, chronic circadian misalignment leads to immune suppression and low-grade systemic inflammation, both of which contribute to impaired tumor immunosurveillance 146

After applying this criterion, 142 DEPs were filtered, and 3 panels associated with the GENUS effect were identified based on their expression pattern, with these proteins being linked to more specific pathways (Fig

5hmC is the main modification status for a many CpGs situated at transcriptionally active regions, such as DNaseI-hypersensitive regions and enhancers [35], suggesting its positive correlation with gene expression [41]