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Reported side effects are rare and typically mild: mild redness or irritation at the application site (usually resolves with continued use or concentration adjustment), occasional skin tingling at higher concentrations (typically benign), and temporary dryness during initial use

Funding Statement This work was supported by grants from the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health (R01AR073172 and 1R21AR083066 to W.T.) and Department of Defense (HT9425-23-10008 to W.T.), and National Heart, Lung, and Blood Institute (R01HL160541 to T.C.) and National Center for Advancing Translational Science (R03TR004450 to T.C.)