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Since mitochondrial problems begin to occur early and because they are shared among species, we first investigated potential changes in metabolite dynamics, especially in the motor cortex of prpTDP-43 A315T mice, which closely recapitulates ALS pathology in patients 16,17,19

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had subjects complete 50 maximal contractions of the elbow flexors while having their blood taken prior to exercise, as well as immediately post-exercise and 24, 48, 72, 96 and 120 h post-exercise

On the other hand, post-acquisition options for normalization are based on the retrieved metabolic profiles