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Li M, Wang M, Guo W, Wang J, Sun X (2011) The effect of caffeine on intraocular pressure: a systematic review and meta-analysis

Monitor how you feel if after sustained use (say 612 months) youre maintaining great energy, you might experiment with a short break to see if theres any difference, always listening to your body
From there, proper handling preserves that quality so your research can be valid and impactful

Gut health as the foundation Why do you insist on fixing the gut first
