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Busulphan (Bu) is a myeloablative drug used for conditioning prior to hematopoietic stem cell transplantation
The integrated PK-PD findings, including nonlinear exposure, target tissue accumulation, and disruption of L-carnitine homeostasis, collectively elucidate mildronates mechanism of action through energy substrate depletion, as well as its intrinsic efficacy-toxicity duality
Children, unless under professional guidance
