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In addition, there is evidence that modulation by Ca 2+ is dependent on the direct binding of calmodulin to the channel, which affects both the activation and inactivation steps (Hasan et al., 2017), although the direct action of Ca 2+ on human TRPA1 has also been demonstrated by calmodulin-independent mechanisms (Moparthi et al., 2020)

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Note, the results were obtained with parenteral and per-oral application (i.e., BPC 157 is stable in gastric juice more than 24 h, unlike standard growth factors) (1-7)