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Journal of Neurology 2005

The ability of ceramides to interfere with insulin receptor signaling is the result of blocking the receptors ability to activate the downstream effector kinase, AKT/PKB

Based on a competitive inhibition mechanism, adding supraphysiological concentrations of glutamine (SPG) inhibited the uptake of neutral amino acids in oocytes expressing human SLC1A5 (ASCT2), the primary glutamine transporter in cancer cells [92,93]

It can induce functional changes resulting in spontaneous pain-like behaviors, mechanical hyperalgesia, thermal hyperalgesia, and cold hyperalgesia (180, 181)
