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Description
doi: 10.1155/2012/835059

GPX1 activity determines how efficiently hydrogen peroxide is cleared before it can participate in Fenton chemistry to generate the highly reactive hydroxyl radical the most damaging ROS in the cellular environment

We find that blockade of de novo GSH synthesis eliminates the protective effects of genetic or pharmacological RNR inhibition on ferroptosis

As a powerful antioxidant, glutathione supports the body's natural defense system, protecting cells from this damage
