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Description
The tight junction is composed of several transmembrane and cytosolic proteins, including occludin, claudins, zonula occludens (ZOs), tricellulin, cingulin, and junctional adhesion molecules (JAM), which interact with each other, as well as with the cytoskeleton, and form a complex architecture 27

Carcinogenesis 33:72331

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Both cell types utilize glucose, oxygen, lactate, and glutamine as potential energy sources in the TME, but differ fundamentally in their reliance on glycolysis versus OXPHOS for ATP production, creating opportunities for metabolic modulation to enhance anti-tumor immunity [28]
