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Lee et al.'s simpler topical approach produced more modest but still significant results suggesting a spectrum from basic topical use to advanced clinical delivery

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27 It is well known that enteroendocrine cells produce low basal levels of GLP-1 during pre-prandial state, however after food ingestion the synthesis and secretion of GLP-1 sharply raises with a peak 3060 min following nutrient intake

The fast component is mediated by GABA A receptors and the slow component by GABA B receptors
