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In contrast, cells with lower senescence burden may have less FOXO4p53 dependence, or may buffer p53 relocalization through other regulators, which might explain the limited apoptosis in younger cultures compared to aged cell cultures
It should be noted that recent studies have shown convergence between these two pathways such that AMPK activation is an upstream event of the NRF2-mediated antioxidant response 53

An essential vitamin yes but it often played second fiddle to vitamin C, D and Omega-3
