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The dual-receptor mechanism of tirzepatide means it is doing things that semaglutide simply cannot do at any dose, so a true one-to-one equivalency does not exist

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Research indicates that 70% to 75% of diabetic individuals experience at least one GI symptom (Krishnasamy and Abell, 2018), with dysphagia (63%), gastroesophageal reflux (41%), early satiety or nausea (10%20%), constipation (60%), and diarrhea (20%) being especially prominent (Concepcin Zavaleta et al., 2021)