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Moreover, while OCCC show intrinsic resistance to conventional platinum-based chemotherapy, OSC exhibit at first sensitiveness to platinum-based chemotherapy, though the majority of cases develop chemoresistance during the course of treatments 33,34

Intracerebroventricular delivery as a safe, long-term route of drug administration
A 30-gauge needle is noticeably more comfortable than a 25-gauge needle

& Tiwari, A
