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Description
The use of HA hydrogels in biomedical applications is particularly favored due to their innate presence in the human body, which contributes to their high degree of compatibility with biological tissues
53,54,55 These niche changes include increased expression of inflammatory cytokines such as CXCL14 and cell cycle inhibitors such as CDKN1C and CDKN2A, coupled with downregulation of ECM and adhesion genes, including CAV1 , SPRY1 , FN1 , and ITGB1
It can result in long-term kidney failure and the need for dialysis or kidney transplantation
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