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This Perspective discusses the emerging cellular roles of lysine lactylation, with a focus on the lactyl-CoA-independent pathway, and highlights the potential strategies of targeting lactylation for the treatment of associated human diseases.

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Across the globe, three out of five people die from conditions linked to chronic inflammation, including heart disease, stroke, diabetes, and cancer

It is, for instance, known thatvitamin E, together withglutathione(GSH) and a membrane-bound heat labile GSH-dependent factor, presumably an enzyme,canprevent damaging effects of reactive oxygen species on polyunsaturated fatty acids in biomembranes (lipid peroxidation)