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CRP was initially supposed to be solely produced by the liver, but currently, various pieces scientific evidence reveal some other extrahepatic sites for CRP production, including neurons, adipose tissue, intestines, renal cortical tubules and lung epithelial cells, coronary and other smooth muscle cells, atherosclerotic plaques (mostly by smooth muscle cells and macrophages), Kupffer cells, active peripheral blood monocytes, (alveolar) macrophages, and lymphocytes [26,35,59]

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Specific interaction of penicillin-binding proteins 3 and 7/8 with soluble lytic transglycosylase in Escherichia coli