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In this regard, the concept of chrononutrition is based on a circadian system that supports wakefulness and eating during the biological day and sleep and fasting during the biological night [5]

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Moreover, transcriptomic and proteomic analyses are needed to investigate the entire TH-dependent transcriptome in the skin

Methods for preparing parenterally administrable compositions are well known in the art and described in more detail in various sources, including, for example, Remington's Pharmaceutical Science (15th ed., Mack Publishing, Easton, PA, 1980) (incorporated by reference in its entirety for all purposes)