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Changes in hypothalamic Kiss1 and Gnrh1 and pituitary Lhb mRNA and circulating LH levels On PND24, hypothalamic Kiss1 and Gnrh1 mRNA levels of rhGH rats were significantly higher than those of control rats, the hypothalamic Kiss1 and Gnrh1 mRNA levels of 2 IU/kg rhGH rats were significantly higher than those of 1 IU/kg rhGH rats on PND 24

In experimental spinal cord injury models, GLPs preserve myelin ultrastructure and enhance functional recovery through multimodal neuroprotective actions: they suppress neuronal and oligodendroglial apoptosisevidenced by reduced caspase-3 cleavageattenuate neuroinflammation via downregulation of TNF- and myeloperoxidase (MPO) activity, and counteract oxidative damage by decreasing MDA and NO levels while boosting SOD activity

Consequences for tissue homeostasis and disease In the previous section, we have discussed how NRF2-regulated cellular metabolism supports the antioxidant program