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Moreover, elderly women with the estrogen receptor 1 allele exhibit significantly smaller WM lesions, suggesting a protective role of estrogen against age-related WM impairments (Ryan et al., 2014)

The role of selenium mineral trace element in exercise: antioxidant defense system, muscle performance, hormone response, and athletic performance

Kahroba H, Ramezani B, Maadi H et al (2021) The role of Nrf2 in neural stem/progenitors cells: from maintaining stemness and self-renewal to promoting differentiation capability and facilitating therapeutic application in neurodegenerative disease

Accordingly, intraarticular injection of senescence cells resulted in enhanced pain, impaired mobility, and OA-associated radiographic and histological alterations of the joint in healthy mice [192]