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Nevertheless, sulphasalazine has been demonstrated to be an effective treatment in cancer models, by inhibiting xCT to activate ferroptosis 232,233 and restore sensitivity to chemotherapy

Taking advantage of the reversibility of Michael addition reaction, we developed the first reversible reaction-based fluorescent probe ThiolQuant Green to perform single-point quantification of GSH in living cells 15

While yeast metabolic engineering has focused on assembling pathways in the cell cytosol, there is growing interest in embracing subcellular compartmentalization

The use of proton magnetic resonance spectroscopy and mass spectroscopy techniques focused on GSH detection in tumors, particularly as an indicator of treatment efficacy and success, taking advantage of the high flux of GSH in and between tumor cells and their microenvironment