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When M2 macrophages were transfected with the IVT mRNA-loaded nanoparticles, gene expression profiles revealed a shift from M2 to a phenotype that more closely resembled the phenotype of inflammatory macrophages (generated separately by culturing BMDMs with TLR4)

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Rinsing the mouth with a solution made by dissolving 1 teaspoon of salt and 1 teaspoon of baking soda in 4 cups of water can also help improve food flavor.