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96 The major endogenous nonenzymatic low-molecular-mass antioxidants include N-acetylcysteine, glutathione, uric acid, melatonin, coenzyme Q and others

Our findings are the first to demonstrate that GCLC desuccinylation mediated by SIRT2 directly regulates the rapid activation of GCLC upon oxidative stress, which provides a promising adjunct therapeutic target for cancer treatment

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