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Description
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Statistical analysis The sample size determination utilized the PASS software

Animal models of obesity and T2D as well show affected BCAA catabolism [75, 111, 112]: tissue-specific expression of BCAA-catabolic enzymes are shown to be dysregulated [23, 27, 79, 108, 113,114,115,116,117,118,119,120,121] especially in adipose tissue [75, 122] and liver [75, 113]

Moreover, IL-6 modulates claudin-2 protein expression through IL-6R-associated signaling transducers and gp130 signaling pathway, consequently enhancing TJ permeability in intestinal epithelium (129)
