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Mendizabal M, Silva MO

Overexpression of Mn superoxide dismutase does not increase life span in mice

10.1139/cjpp-2012-0279 103 PaschalD

This concept has evolved over the last years, and Green and colleagues proposed the dual effector hypothesis, postulating that GH regulates the expression of locally produced IGF-1, which then acts in an autocrine/paracrine manner (12)
