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Increased free radical production may be associated with impaired Nitric Oxide bioavailability

Functionally, this polymorphism modulates both the efficacy and safety of SSRI therapy: individuals carrying the S allele tend to exhibit blunted antidepressant response, slower onset of remission, and increased susceptibility to adverse effects, particularly when exposed to stressful environmental factors that intensify serotonergic dysregulation (Figure 2) ( FIGURE 2 In pharmacodynamic terms, 5-HTTLPR variation alters the neural homeostasis that underlies treatment response

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Increased risk of respiratory disease and diarrhea in children with preexisting mild vitamin A deficiency