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They could provide a proper diagnosis and treatment plan.

The remarkable efficacy of metabolic reprogramming strategies in murine models often fails to translate into consistent benefits in human patients, a discrepancy largely attributable to the greater complexity and heterogeneity of the human tumor microenvironment

30 Also, the onset of acute pancreatitis occurred after 12 months in the LEADER trial and after more than five to six months in the SCALE trial, indicating that the likelihood of developing pancreatitis was influenced more by the rate and degree of weight loss than the drug itself

Senescent fibroblasts and endothelial cells, through the secretion of SASPparticularly PDGF-Apromote an increase in myofibroblast numbers at wound sites, which positively affects wound healing [141]