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For example, a previous study explored recent advances in gut flora and its metabolites in typical lung diseases ( Table 1 ), such as pulmonary hypertension, chronic obstructive pulmonary disease and lung cancer (43)

Deficiency can occur due to dietary limitations, digestive disorders, or certain medications that interfere with B12 absorption

For example, KAR5585 (rodatristat ethyl) has emerged as a promising first-in-class oral tryptophan hydroxylase 1 (TPH1) inhibitor

This regulatory mechanism underscores DJ-1s crucial role in cellular defense against oxidative stress, highlighting its potential as a therapeutic target for neurodegenerative diseases and conditions involving oxidative damage (Ge et al., 2022
