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The VPA_RAT group exhibited lower species richness than the Control group, evidenced by reduced values in Chao1 (Figure S3A), Faith PD (Figure S3B), and observed features indices (Figure S3C)

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However, the structurally modified version of the tetra-substituted peptide, Modified GRF 1-29, is considered to boast a longer half-life and has, therefore, been considered by researchers as a more viable compound for use during experimental research