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doi: 10.1073/pnas.1200189109 118 PetraroiaIGhidottiPBertoliniGPontisFRozLBalsamoMet al
Novel defects in collagen XII and VI expand the mixed myopathy/EhlersDanlos syndrome spectrum and lead to variant-specific alterations in the extracellular matrix
However, susceptibility to proteolytic degradation and limited membrane permeability restrict their action to intracellular antioxidant pathways, thereby precluding the systemic immunomodulatory effects observed in other radioprotectants
thus a functional iron deficiency presenting as iron overload cannot be excluded by measuring total markers of iron
